Document Actions
Publications
2011
Bingel U, Wanigasekera V, Wiech K, Ni Mhuircheartaigh R, Lee MC, Ploner M, Tracey I: The effect of treatment expectation on drug efficacy: imaging the analgesic benefit of the opioid remifentanil. Science and Translational Medicine, 2011 3:70ra14.
Gwilym SE, Oag HC, Tracey I, Carr AJ: Evidence that central sensitisation is present in patients with shoulder impingement syndrome and influences the outcome after surgery. J Bone Joint Surg Br, 2011, 93:498-502.
Kahane G, Wiech K, Shackel N, Farias M, Savulescu J, Tracey I: The neural basis of intuitive and counterintuitive moral judgment. 2011, Soc Cogn Affect Neurosci.
Leknes S, Lee M, Berna C, Andersson J, Tracey I: Relief as a reward: hedonic and neural responses to safety from pain. PLoS One 2011 6:e17870.
Ploner M, Lee MC, Wiech K, Bingel U, Tracey I: Flexible cerebral connectivity patterns subserve contextual modulations of pain. Cereb Cortex, 2011 21:719-726.
Tracey I Can neuroimaging studies identify pain endophenotypes in humans? Nat Rev Neurol 7:173-181.
Vincent K, Warnaby C, Stagg CJ, Moore J, Kennedy S, Tracey I Dysmenorrhoea is associated with central changes in otherwise healthy women. Pain, 2011
Wanigasekera V, Lee MC, Rogers R, Hu P, Tracey I (2011) Neural correlates of an injury-free model of central sensitization induced by opioid withdrawal in humans. J Neurosci 31:2835-2842.
2010
Baumgartner U, Iannetti GD, Zambreanu L, Stoeter P, Treede RD, Tracey I: Multiple somatotopic representations of heat and mechanical pain in the operculo-insular cortex: a high-resolution fMRI study. J Neurophysiology, 2010 104:2863-2872.Berna C, Leknes S, Holmes EA, Edwards RR, Goodwin GM, Tracey I (2010) Induction of depressed mood disrupts emotion regulation neurocircuitry and enhances pain unpleasantness. Biol Psychiatry 67:1083-1090.
Gwilym SE, Filippini N, Douaud G, Carr AJ, Tracey I (2010) Thalamic atrophy associated with painful osteoarthritis of the hip is reversible after arthroplasty: a longitudinal voxel-based morphometric study. Arthritis Rheum 62:2930-2940.
Lee MC, Tracey I (2010) Unravelling the mystery of pain, suffering, and relief with brain imaging. Curr Pain Headache Rep 14:124-131.
Mhuircheartaigh RN, Rosenorn-Lanng D, Wise R, Jbabdi S, Rogers R, Tracey I (2010) Cortical and subcortical connectivity changes during decreasing levels of consciousness in humans: a functional magnetic resonance imaging study using propofol. J Neurosci 30:9095-9102.
Tracey I (2010) Getting the pain you expect: mechanisms of placebo, nocebo and reappraisal effects in humans. Nat Med 16:1277-1283.
Vincent K, Tracey I (2010) Sex hormones and pain: the evidence from functional imaging. Curr Pain Headache Rep 14:396-403.
Wiech K, Lin CS, Brodersen KH, Bingel U, Ploner M, Tracey I (2010) Anterior insula integrates information about salience into perceptual decisions about pain. J Neurosci 30:16324-16331.
Wise RG, Pattinson KT, Bulte DP, Rogers R, Tracey I, Matthews PM, Jezzard P (2010) Measurement of relative cerebral blood volume using BOLD contrast and mild hypoxic hypoxia. Magn Reson Imaging 28:1129-1134.
Ploner M, Lee MC, Wiech K, Bingel U, Tracey I; Prestimulus functional connectivity determines pain percepion in humans, Proceedings of the Natural Academy of Sciences U.S.A, 2010; 107(1):355-60.
Tracey I, Johns E.: The pain matrix: Reloaded or reborn as we image tonic pain using arterial spin labelling, Pain, 2010; Jan 15 E-pub ahead of print.
2009
Stephen E. Gwilym, John R. Keltner, Catherine E. Warnaby, Andrew J. Carr, Boris Chizh, Iain Chessell, Irene Tracey: Psychophysical and functional imaging evidence supporting the
presence of central sensitization in a cohort of osteoarthritis
patients, Arthritis Care and Research, 2009; 61(9):1226-1234.
Mayer EA, Aziz Q, Coen S, Kern M, Labus JS, Lane R, Kuo B, Naliboff B, Tracey I: BrainImaging approaches to the study of functional GI disorders: a Rome working team report. Neurogastroenterology and Motility, 2009; 21(6):579-96.
Pattinson KT, Mitsis GD, Harvey AK, Dirckx S, Mayhew SD, Rogers R, Tracey I, Wise RG: Determination of the human brainstem respiratiry control netwrok and its cortical connections in vivo using functional and structural imaging. Neuroimage, 2009; 44(2):295-305.
Pattinson KT, Governo RJ, MacIntosh BJ, Russell EC, Corfield DR, Tracey I, Wise RG: Opioids depress cortical centers responsible for the volitional control of respiration. Journal of Neuroscience, 2009; 29(25):8177-86.
Tracey I, Bushnell MC. How neuroimaging studies have challenged us to rethink: is chronic pain a disease?, Journal of Pain, 2009; 10(11):113-20.
Vincent K, Moore J, Kennedy S, Tracey I: Blood oxygenation level dependent functional magnetic resonance imaging: current and potential uses in obstetrics and gynaecology. British Journal of Obstetrics and Gynaecolgy, 2009; 116(2):240-6.Wartolowska K, Tracey I: Neuroimaging as a tool for pain diagnosis and analgesic development. Neurotherapeutics, 2009; 6(4):755-60.
Watson A, El-Deredy W, Iannetti GD, Lloyd D, Tracey I, Vogt BA, Nadeau V, Jones AK. Placebo conditioning and placebo analgesia modulate a common brain network during pain anticipation and perception. Pain, 2009; 145(1-2):24-30.
Wiech K, Tracey I: The influence of negative emotions on pain: behavioral effects an neural mechanisms. Neuroimage, 2009; 47(3):987-94.
2008
Bingel U, Tracey I: Imaging CNS modulation in humans. Physiology, 2008; 23:371-80Brooks JC, Beckmann CF, Miller KL, Wise RG, Porro CA, Tracey I, Jenkinson M: Physiological noise modelling for spinal functional magnetic resonance imaging studies. Neuroimage, 2008; 39:680-692.
Langley CK, Aziz Q, Bountra C, Gordon N, Hawkin P, Jones A, Langley G, Nurmikko T, Tracey I: Volunteer studies in pain research--opportuntities and challenges to replace animal experiments: the report and recommendations of a Focus on Alternatives workshop. Neuroimage, 2008; 42: 467-473.
Lee MC, Zambreanu L, Menon DK, Tracey I: Identifying brain activity sepcifically related to the maintenance and perceptual consequence of central sensitziation in humans. Journal of Neuroscience, 2008; 28(45):11642-9
Leknes S, Brooks JC, Wiech K, Tracey I: Pain relief as an opponent process: a psychophysical investigation. European Journal of Neuroscience, 2008; 28: 794-801
Leknes S, Tracey I: A common neurobiology for pain and pleasure. Nature Review Neuroscience, 2008; 9:314-320.
Matthews PM, Radda GK, Johansen-Berg H, Tracey I, Cowey A: Remembering John Newsom-Davis' contribution to human imaging in Oxford. Journal of Neuroimmunology, 2008; 201-202:250-4.
Mitsis GD, Iannetti GD, Smart TS, Tracey I, Wise RG: Regions of interest analysis in pharmacological fMRI: How do the definition criteria influence the inferred result? Neuroimage, 2008; 40:121-132.
Schweinhardt P, Kalk N, Wartolowska K, Chessell I, Wordsworth P, Tracey I: Investigation into the neural correlates of emotional augmentation of clinical pain. Neuroimage, 2008; 40:759-766.
Tracey I: Imaging pain. British Journal of Anaesthesia, 2008; 101:32-39
Wiech K, Ploner M, Tracey I: Neurocognitive aspects of pain perception. Trends in Cognitive Science, 2008; 12:306-313.
Wiech k, Farias M, Kahane G, Shackel N, Tiede W, Tracey I: An fMRI study measuring analgesia enhanced by religion as a belief system. Pain, 2008; 139(2):467-76
2007
Brooks JC, Tracey I: The insula: a multidimensional integration site for pain. Pain, 2007; 128:1-2.
Dunckley P, Aziz Q, Wise RG, Brooks J, Tracey I, Chang L: Attentional modulation of visceral and somatic pain. Neurogastroenterology and Motility, 2007; 19(7):569-77.
Fairhurst M, Wiech K, Dunckley P, Tracey I: Anticipatory brainstem activity predicts neural processing of pain in humans. Pain, 2007; 128:101-110.
Leknes SG, Bantick S, Willis CM, Wilkinson JD, Wise RG, Tracey I: Itch and motivation to scratch: an investigation of the central and peripheral correlates of allergen- and histamine-induced itch in humans. Journal of Neurophysiology, 2007; 97:415-422.
Maieron M, Iannetti GD, Bodurka J, Tracey I, Bandettini PA, Porro CA: Functional responses in the human spinal cord during willed motor actions: evidence for side- and rate-dependent activity. Journal of Neuroscience, 2007; 27:4182-4190.
Pattinson KT, Rogers R, Mayhew SD, Tracey I, Wise RG: Pharmacological FMRI: measuring opioid effects on the BOLD response to hypercapnia. Journal of Cerebral Blood Flow and Metabolism, 2007; 27:414-423.
Tracey I, Mantyh PW: The cerebral signature for pain perception and its modulation. Neuron, 2007; 55(3):377-91.
Tracey I, Neuroimaging of pain mechanisms, Current Opinion Supportive Palliatiative Care, 2007; Aug;1(2):109-16.
Wise RG, Pattinson KT, Bulte DP, Chiarelli PA, Mayhew SD, Balanos GM, O'Connor D F, Pragnell TR, Robbins PA, Tracey I, et al.: Dynamic forcing of end-tidal carbon dioxide and oxygen applied to functional magnetic resonance imaging. Journal of Cerebral Blood Flow and Metabolism, 2007; 27(2):414-23.
Wise RG, Lujan BJ, Schweinhardt P, Peskett GD, Rogers R, Tracey I: The anxiolytic effects of midazolam during anticipation to pain revealed using fMRI. Magnetic Resonance Imaging, 2007; 25(6):801-10.
2006
Hadjipavlou G, Dunckley P, Behrens TE, Tracey I: Determining anatomical connectivities between cortical and brainstem pain processing regions in humans: A diffusion tensor imaging study in healthy controls. Pain, 2006; 123(1-2): 169-178.
Iannetti GD,
Zambreanu L, Tracey I: Similar
nociceptive afferents mediate psychophysical and electrophysiological
responses
to heat stimulation of glabrous and hairy skin in humans. Journal of Physiology, 2006;
577:235-248.
Schweinhardt P, Glynn C, Brooks J, McQuay H, Jack T, Chessell I, Bountra C, Tracey I: An fMRI study of cerebral processing of brush-evoked allodynia in neuropathic pain patients. Neuroimage 2006, 32(1):256-65.
Schweinhardt P, Lee M, Tracey I: Imaging pain in patients: is it meaningful? Current Opinion in Neurology 2006, 19(4):392-400.
Tracey I, Iannetti GD: Brainstem functional imaging in humans. Supplements to Clinical Neurophysiology 2006, 58:52-67.
Wise RG, Tracey I: The
role
of fMRI in drug
discovery. Journal of Magnetic
Resonance Imaging 2006, 23:862-876.
2005
Dunckley P, Wise R, Fairhurst M, Hobden P, Aziz Q, Chang L, Tracey I: A comparison of visceral and somatic pain processing in the human brainstem using functional magnetic resonance imaging. Journal of Neuroscience 2005, 25(32): 7333-41.
Iannetti GD, Zambreanu L, Wise RG, Buchanan TJ, Huggins JP, Smart TS, Vennart W, Tracey I: Pharmacological modulation of pain-related brain activity during normal and central sensitization states in humans. Proceedings of the Natural Academy of Science U S A 2005, 102:18195-18200.
Iannetti G, Niazy R, Wise R, Jezzard P, Brooks J, Zambreanu L, Vennart W, Matthews P, Tracey I: Simultaneous recording of laser-evoked brain potentials during continuous high-field functional magnetic resonance imaging in humans. Neuroimage 2005, 28(3):708-19.
Iannetti GD, Zambreanu L, Cruccu G, Tracey I: Operculoinsular cortex encodes pain intensity at the earliest stages of cortical processing as indicated by amplitude of laser-evoked potentials in humans. Neuroscience 2005, 131:199-208.
Iannetti GD, Zambreanu L, Tracey I: Response to Dr Ochoa. Pain 2005, 117:236-237.
Tjandra T, Brooks JC, Figueiredo P, Wise R, Matthews PM, Tracey I: Quantitative assessment of the reproducibility of functional activation measured with BOLD and MR perfusion imaging: Implications for clinical trial design. Neuroimage 2005, 27(2): 393-401.
Tracey I: Taking the Narrative out of Pain: Objectifying Pain through Brain Imaging. In Narrative, Pain and Suffering. Edited by Carr D, Loeser J, Morris D: IASP Press; 2005:127-163. Progress in Pain Research and Management, vol 34.
Tracey I: Nociceptive processing in the human brain. Current Opinion in Neurobiology 2005, 15(4):478-87.
Tracey I: Functional connectivity and pain: how effectively connected is your brain? Pain 2005, 116:173-174.
Tracey I, Ingvar M: Imaging Pain II. Basic Aspects of the Headaches. In The Headaches, edn 3rd. Edited by Olesen J, Tfelt-Hansen P, Welch K, Goadsby P, Ramadan N: Lippincott Williams and Wilkins; 2005:129-139.Tracey I, Schweinhardt P, Bountra C: Brain FMRI in Clinical Pharmacological Studies. In In Vivo MR techniques in Drug Discovery and Development. Edited by Beckmann N: CRC Press LLC; CRC Press Series Pharmacology and Toxicology: Basic & Clinical Aspects; 2005.
2004
Iannetti GD, Leandri M, Truini A, Zambreanu L, Cruccu G, Tracey I: Adelta nociceptor response to laser stimuli: selective effect of stimulus duration on skin temperature, brain potentials and pain perception. Clinical Neurophysiology 2004, 115:2629-2637.2002
Lee AC, Robbins TW, Smith S, Calvert GA, Tracey I, Matthews P, Owen AM: Evidence for asymmetric frontal-lobe involvement in episodic memory from functional magnetic resonance imaging and patients with unilateral frontal-lobe excisions. Neuropsychologia 2002, 40:2420-2437.
Smith KA, Ploghaus A, Cowen PJ, McCleery JM, Goodwin GM, Smith S, Tracey I, Matthews PM: Cerebellar responses during anticipation of noxious stimuli in subjects recovered from depression. Functional magnetic resonance imaging study. British Journal of Psychiatry 2002, 181:411-415.
Tracey I, Ploghaus A, Gati JS, Clare S, Smith S, Menon RS, Matthews PM: Imaging attentional modulation of pain in the periaqueductal gray in humans. Journal of Neuroscience 2002, 22:2748-2752.
Wise RG, Rogers R, Painter D, Bantick S, Ploghaus A, Williams P, Rapeport G, Tracey I: Combining fMRI with a pharmacokinetic model to determine which brain areas activated by painful stimulation are specifically modulated by remifentanil. Neuroimage 2002, 16:999-1014.
2001
Ploghaus A, Narain C, Beckmann CF, Clare S, Bantick S, Wise R, Matthews PM, Rawlins JN, Tracey I: Exacerbation of pain by anxiety is associated with activity in a hippocampal network. Journal of Neuroscience 2001, 21:9896-9903.
Tracey I: Prospects for human pharmacological functional magnetic resonance imaging (phMRI). Journal of Clinical Pharmacology 2001, Suppl:21S-28S.
2000
Ploghaus A, Tracey I, Clare S, Gati JS, Rawlins JN, Matthews PM: Learning about pain: the neural substrate of the prediction error for aversive events. Proceedings of the Natural Academy of Science U S A 2000, 97:9281-9286.
Stern CE, Owen AM, Tracey I, Look RB, Rosen BR, Petrides M: Activity in ventrolateral and mid-dorsolateral prefrontal cortex during nonspatial visual working memory processing: evidence from functional magnetic resonance imaging. Neuroimage 2000, 11:392-399.
Tracey I, Becerra L, Chang I, Breiter H, Jenkins L, Borsook D, Gonzalez RG: Noxious hot and cold stimulation produce common patterns of brain activation in humans: a functional magnetic resonance imaging study. Neuroscience Letters 2000, 288:159-162.
1999
Ploghaus A, Tracey I, Gati JS, Clare S, Menon RS, Matthews PM, Rawlins JN: Dissociating pain from its anticipation in the human brain. Science 1999, 284:1979-1981.Miscellaneous other publications by Irene Tracey
Kunz WS, Kuznetsov AV, Clark JF, Tracey I, Elger CE: Metabolic consequences of the cytochrome c oxidase deficiency in brain of copper-deficient Mo(vbr) mice. Journal of Neurochemistry 1999, 72:1580-1585.
Tracey I, Hamberg LM, Guimaraes AR, Hunter G, Chang I, Navia BA, Gonzalez RG: Increased cerebral blood volume in HIV-positive patients detected by functional MRI. Neurology 1998, 50:1821-1826.
Owen AM, Stern CE, Look RB, Tracey I, Rosen BR, Petrides M: Functional organization of spatial and nonspatial working memory processing within the human lateral frontal cortex. Proceedings of the Natural Academy of Science U S A 1998, 95:7721-7726.
Tracey I, Dunn JF, Radda GK: A 31P-magnetic resonance spectroscopy and biochemical study of the mo(vbr) mouse: potential model for the mitochondrial encephalomyopathies. Muscle Nerve 1997, 20:1352-1359.
Tracey I, Lane J, Chang I, Navia B, Lackner A, Gonzalez RG: 1H magnetic resonance spectroscopy reveals neuronal injury in a simian immunodeficiency virus macaque model. Journal of Acquired Immune Deficiency Syndromes & Human Retrovirology 1997, 15:21-27.
Cheng LL, Ma MJ, Becerra L, Ptak T, Tracey I, Lackner A, Gonzalez RG: Quantitative neuropathology by high resolution magic angle spinning proton magnetic resonance spectroscopy. Proceedings of the Natural Academy of Science U S A 1997, 94:6408-6413.
Tracey I, Dunn JF, Parkes HG, Radda GK: An in vivo and in vitro H-magnetic resonance spectroscopy study of mdx mouse brain: abnormal development or neural necrosis? Journal of the Neurological Sciences 1996, 141:13-18.
Tracey I, Dunn JF, Radda GK: Brain metabolism is abnormal in the mdx model of Duchenne muscular dystrophy. Brain 1996, 119 ( Pt 3):1039-1044.
Tracey I, Carr CA, Guimaraes AR, Worth JL, Navia BA, Gonzalez RG: Brain choline-containing compounds are elevated in HIV-positive patients before the onset of AIDS dementia complex: A proton magnetic resonance spectroscopic study. Neurology 1996, 46:783-788.
Rae C, Scott RB, Thompson CH, Kemp GJ, Dumughn I, Styles P, Tracey I, Radda GK: Is pH a biochemical marker of IQ? Proceedings of the Royal Society B: Biological Sciences 1996, 263:1061-1064.
Tracey I, Scott RB, Thompson CH, Dunn JF, Barnes PR, Styles P, Kemp GJ, Rae CD, Pike M, Radda GK: Brain abnormalities in Duchenne muscular dystrophy: phosphorus-31 magnetic resonance spectroscopy and neuropsychological study. Lancet 1995, 345:1260-1264.
Dunn JF, Tracey I, Radda GK: Exercise metabolism in Duchenne muscular dystrophy: a biochemical and [31P]-nuclear magnetic resonance study of mdx mice. Proceedings of the Royal Society B: Biological Sciences 1993, 251:201-206.
Dunn JF, Tracey I, Radda GK: A 31P-NMR study of muscle exercise metabolism in mdx mice: evidence for abnormal pH regulation. Journal of the Neurological Sciences 1992, 113:108-113.
Seth Smith (Vanderbilt School of Engineering, Nashville)
Postdoctoral MR Physicist Position