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Hybrid inference approach

Firstly, we can determine bounds on the accuracy of the fast approximation's z-statistic bounds by using artificial data with ``worst case scenario'' variance components by comparing the [LOWER] and [UPPER] inference approaches with [BIDET] (as described in section 6). For the design matrices we are using here, the corresponding artificial dataset we need to use is Dataset 1 from section 6.

We can then run the fast approximation approach on our real FMRI data first, and subsequently only run the computationally expensive MCMC sampling (with 30,000 samples and a burnin of 1000 samples) and the fitting of a non-central multivariate t-distribution (BIDET, section 3.7) on voxels at which the desired $ z$ threshold lies within the estimated bounds.

This hybrid approach takes approximately 1 hour (for the datasets considered here) on a 2GHz Intel PC on a full volume.